The Endocannabinoid System
What is the Endocannabinoid System?
The Endocannabinoid System is a complex system within the body that sends signals to the cells. There are three major parts to the system, enzymes, receptors, and endocannabinoids. The body makes these molecules. Endocannabinoids are similar to cannabinoids, such as CBD. Researchers have isolated two critical endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG). The body produces them as they are needed, and they help the body run at peak conditions.
Endocannabinoids bind to endocannabinoid receptors to send a signal that the body needs help from the Endocannabinoid System. Since endocannabinoid receptors are throughout the body, the Endocannabinoid System can send help to a specific part of the body. Two receptors handle most of the work throughout the body. One of the receptors, CB1, is found in the central nervous system, and CB2 is located in the peripheral nervous system, like immune cells. Depending on which receptor the endocannabinoids bind to dictates how the body responds and how it benefits the body.
The enzymes in the body break down the endocannabinoids once they have completed their role. For example, fatty acid amide hydrolase breaks down AEA, and monoacylglycerol acid lipase breaks down 2-AG.
How the Endocannabinoid System Impacts Mental Health
The Endocannabinoid System helps regulate sleep and mood, among other functions of the body. It can improve emotion, cognition, and mental health, which are all processes of the brain. There are high levels of CB1 in several regions of the brain, such as the hippocampus, neocortex, cerebellum, and hypothalamus. These are the areas of the brain active when you have an emotional or behavioral reaction. For example, when the CB1 receptor is blocked, it causes anxiety to increase.
Researchers also found that the endocannabinoid 2-AG is key to regulating emotions and emotional behavior. When there is a smaller amount of 2-AG, there is an increase in depression and anxiety. Conversely, an increase in 2-AG means there is a decrease in depression and anxiety. Anxiety disorders include depression, phobia, panic disorders, and post-traumatic stress disorder (PTSD). Many people live with anxiety and other mental health conditions. It is found that these conditions are often worsened by stress. When the Endocannabinoid System is working correctly, there is a reduction in stress throughout the body.
The Endocannabinoid System, Omega-3 Index, Mentanine®, and Mental Health Disorders
Our research shows that an increased Omega-3 Index will have a positive effect on the Endocannabinoid System (EDC). Although the researchers are not quite sure about the specific functions, they know that Essential Fatty Acids (EFAs) have a positive interaction. The EFAs prevent endocannabinoids from breaking down. This gives the endocannabinoids the ability to make a positive impact for an extended time. The CB1 and CB2 receptors are part of the Endocannabinoid System. To improve the health of both receptors, the health of the Endocannabinoid System must be improved. The only practical improvement method for the EDC is to increase the Omega-3 Index and in effect, increase the percentage of EPA and DHA in the bloodstream.
Mentanine® formulation bypasses the CB1 and CB2 receptors through the newly discovered pathway of PPAR receptors and enables the formula to enter the central nervous system (the brain) and target the portion of the brain that deals with emotions, such as anxiety and depression.
Depression is among the most common mental health conditions. Our formulation has antidepressant impacts on the body because it interacts with the serotonin receptors in the brain. If you have lower levels of serotonin in your body, feelings of depression can be more prevalent. Conversely, when there are higher serotonin levels in the body, the feelings of depression are less prevalent. Mentanine® compounds can interact with the serotonin that is in the body and help the body and the brain better respond in a more positive way. Those living with mental disorders or stress often have irregular sleep patterns or do not sleep at all. When stress is reduced, people often find it easier to sleep. Sleep is important for overall general and mental health. When you do not get proper rest, it is difficult for your brain to function correctly. We believe our formula can help you get a restful sleep, allowing your brain to function optimally, which can help with anxiety and depression.